Reduced fertility potential

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This topic contains 10 replies, has 11 voices, and was last updated by Apple Apple 1 year, 1 month ago.

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  • #166
    Victoria
    Victoria
    Participant

    I heard that EFS do not predict a reduced fertility potential in future cycles. Nevertheless, whatever the cause of EFS, such patients should be counseled regarding its possibility of recurrence and future poor prognosis.Is it true?What is the cause of EFS?

    #251
    Alice
    Alice
    Participant

    EFS might stem from the same cause that is responsible for the patient’s infertility.Various hypotheses have been put forth ranging from human error to pharmacological problems. Possible etiologies for EFS include: Dysfunctional folliculogenesis, in which early oocyte atresia occurs with apparently normal hormonal response,Biological abnormality in the supply of mature oocytes that can be retrieved, despite normal bioavailability of hCG, Genetic factors in some cases, Drug-related causes due to an abnormality in the in vivo biological activity of some batches of commercially available hCG or GnRH agonist; inappropriate timing of hCG, or rapid clearance of hCG by the liver, and Advanced ovarian ageing through altered folliculogenesis.

    #296
    Kate
    Kate
    Participant

    EFS is reported to occur in about 0.2-7% of IVF cases and most of these cases are sporadic. The incidence is higher in GnRH agonist downregulated cycles. GEFS is reported to recur in subsequent IVF cycles with a recurrence rate of about 20% and the risk increases with age as the chance of recurrence after the age of 40 is found to be about 57%. Various therapeutic strategies are reported in the literature to overcome this condition but the success of obtaining oocytes may not be guaranteed. The treatment option consists of rescheduling of oocyte retrieval 24-36 h after the second dose of hCG, if the hCG level is low on the day of oocyte retrieval. One can also administer the GnRH agonist for the final follicular maturation in a GnRH antagonist cycle. One could try using a different batch of urinary hCG or use recombinant hCG or LH for the trigger. At times, an oocyte retrieval few hours after the first retrieval may be of help.

    #320
    Milka
    Milka
    Participant

    A young patient with few oocytes may still have one or two eggs capable of resulting in a live-birth. Ovarian reserve testing identifies patients that have a lower probability of conceiving. Such tests address averages and not individuals. I will personally never forget one patient who at 33 years of age failed her clomid challenge test and several IVF stimulation attempts. She subsequently delivered a term infant by spontaneous conception two years after the delivery of donor egg twins. When making the choice to move on to donor eggs or adoption be sure that you have explored all available treatment options to your satisfaction.

    #349
    Molly
    Molly
    Participant

    Frequently, when following vigorous and often repeated flushing of follicles at egg retrieval they fail to yield eggs, it is ascribed to “Empty Follicle Syndrome.” This is a gross misnomer, because all follicles contain eggs. So why were no eggs retrieved from the follicles? Most likely it was because they would/could not yield the eggs they harbored.This situation is most commonly seen in older women, women who have severely diminished ovarian reserve, and in women with polycystic ovarian syndrome (PCOS). In my opinion it is often preventable when an optimal, individualized and strategic protocol for controlled ovarian stimulation (COS) is employed and the correct timing and dosage is applied to the “hCG trigger shot.”Normally, following optimal ovarian stimulation, the hCG “trigger shot” is given for the purpose of it triggering meiosis (reproductive division) that is intended to halve the number of chromosomes from 46 to 23 within 32-36 hours. The hCG trigger also enables the egg to signal the “cumulus cells” that bind it firmly to the inner wall of the follicle (through enzymatic activity), to loosen or disperse, so that the egg can detach and readily be captured at egg retrieval (ER).

    #424
    Monica
    Monica
    Participant

    A couple’s most fertile time of day is between 5pm and 7pm. The number and quality of sperm varies throughout the day, peaking in late afternoon with a sperm count that is 35% higher than it is in the morning. Since women are most likely to ovulate between 3 and 7, some researchers suggest couples leave work early for a baby-making rendezvous.And, of course, it is essential that you have sex when you are fertile. You can determine when you are ovulating by using an ovulation detection kit or by practicing FAM (Fertility Awareness Method). By observing your waking temperature, cervical fluid and cervical position you can pinpoint the days when you are able to conceive. Taking Charge of Your Fertility by Toni Weschler has sample charts and detailed instructions on how to use FAM.

    #499
    Bridget
    Bridget
    Participant

    EFS is a frustrating condition in which no oocytes (eggs) are retrieved at IVF, even though ultrasound and estradiol (female hormone measured in the blood) showed the presence of many potential follicles.The mechanism responsible for EFS remains obscure. Many hypotheses have been put forward, but none truly explain this syndrome. The most likely cause of EFS is ovarian aging, as many patients who suffer from EFS are also reduced responders. It is also possible that a patient may experience EFS if the trigger injection is mistimed. The egg collection procedure is usually scheduled for 36 hours after the trigger injection is administered. Much later than this can result in the eggs being ovulated from the ovary before the doctor has been able to perform the procedure.

    #681

    Daria
    Participant

    The term “birth control” carries with it at least a threefold meaning. Usually it is used to indicate contraceptives, i.e. any actions and methods that prevent conception during sexual intercourse; it is this, rather narrow sense and mean Sanger (1883-1966), has offered this term. In an even more narrow sense of “birth control” is understood as the use of chemical or mechanical contraception. However, just this term shall mean any deliberate action to change the number of offspring. In this sense it is earlier or later marriage, infertility treatment, the use of contraception, abstinence from sexual intercourse, as well as permission or prohibition of abortion.

    #709
    Ana
    Ana
    Participant

    i think that you understand that there are different causes of it. the cause of the disease is not known. but i think that genetic plays very important role in it and to my mind it is really possible that it can be inherited. the condition appears to run in families, and sisters of those with it are twice as likely to have it. i have read that it can be the genetic but sometimes the immune system plays very important role in it. the reason also may be dysfunctional folliculogenesis, in which oocyte atresia occurs with normal hormonal response. there are different resosns.

    #778

    Donna
    Participant

    waste is needed not only in order to attract high-quality father-producer. Lack as excess body fat may cause hormonal imbalance. As a result, too large or too skinny girls develop eggs by the ovaries is disturbed. Fortunately, not permanently, but only until the weight does not come back to normal. To its definition of a Belgian sociologist and statistician Adolphe Quetelet invented BMI – body mass index. To calculate it, you need your weight divided by the square of height . It is believed that the potential mother’s BMI should range between 20 and 25 units. Going beyond these limits – is the risk. Recently, in the Netherlands, a study was conducted which showed that for each unit above $ 29, fertility decreases by 4%.

    #855
    Apple
    Apple
    Participant

    I think that malnutrition, against which there is a lack of vitamins and minerals needed for healthy eyes. Toxins accumulated in the body, prevent normal absorption of nutrients, as well as have a negative impact on health, including the eye.
    Smoking and alcohol worsen heart and blood vessels, because of which the necessary amount of oxygen and nutrients are not supplied to the muscles and retina. Problems with the spine.
    Degenerative disc disease, pinched discs and a number of other diseases impair the ability to see.

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